Document Type
Proposal
Publication Date
Spring 4-2025
Department
Chemistry & Physics
Faculty Advisor
Dr. Andrew Yeagley
Abstract
Antimicrobial agents are one of the most important tools used in the medical industry. With the ever growing numbers of antibiotic resistant bacteria, new strategies have been developed to combat them, one of which being biofilm inhibiting agents. A class of molecules called hemibastadins, first discovered from sea sponges, have been of recent interest in the field. Building from previous work done in this lab on hemibastadins, a hemibastadin derivative containing a triazole in place of the oxime has been identified as a potential antibiofilm agent. This work will target a derivative that will more closely mimic the hemibastadins found naturally than the prior work. The molecule will be produced over the course of a nine step synthesis from the starting material, methyl gallate, an accessible cost-effective candidate. The synthesis showcases an innovative divergent then convergent strategy.
Recommended Citation
Daniel, James B. III, "Click-Based Synthesis of Hemibastadin Derivatives and Their Applications as Antimicrobial and Biofilm Inhibiting Agents" (2025). Longwood Senior Thesis Proposal. 21.
https://digitalcommons.longwood.edu/senior_thesis_proposals/21
