Title
Double Gene Knockout of PDX-1 and HNF1β Leads to Possible Novel Gene Therapy for Type 1 Diabetes
Document Type
Poster
Publication Date
Spring 2019
Abstract
Diabetes Mellitus is a disease characterized by uncontrolled and elevated blood glucose which is the effect of inadequate levels of plasma insulin. Type I diabetes (T1D) ultimately stems from the autoimmune destruction of beta cells because of defects in the PDX-1 and possibly HNF1B. If both of these genes knocked out together increase the detriment effect of T1D, then a gene therapy can be created using the AAV vectors that not only targets one gene but both at the same time, increasing the strength of the gene therapy and the quality of life for the T1D patient.
Recommended Citation
Kosiorek, Kathryn, "Double Gene Knockout of PDX-1 and HNF1β Leads to Possible Novel Gene Therapy for Type 1 Diabetes" (2019). Spring Showcase for Research and Creative Inquiry. 27.
https://digitalcommons.longwood.edu/rci_spring/27
Comments
Faculty Adviser: Dr. Amorette Barber