Ability of Flavonoids to Mimic the Estrogen Receptor to Drive Myeloid Derived Suppressor Cell Differentiation

Authors

Megan Bland, Longwood UniversityFollow
Cecilie Elliott, Longwood UniversityFollow
Kathryn Kosiorek, Longwood UniversityFollow

Document Type

Poster

Publication Date

Spring 2019

Abstract

Flavonoids are natural compounds found in dietary elements such as soy, grains, and vegetables that have the potential to bind to the estrogen receptor. Activation of the estrogen receptor drives myeloid derived suppressor cell (MDSC) accumulation, cells that increase during cancer, inflammation, and infection. In this study, we are investigating specific flavonoids, such as epigallocatechin-3-gallate (EGCG), kaempferol, naringenin, daidzein, and genistein, for their ability to mimic estrogen. After examination, we expect that MDSC differentiation will decrease upon treatment of the chosen flavonoids, leading to reduced carcinogenic effects.

Comments

Faculty Adviser: Dr. Amorette Barber

Recommended Citation

Bland, Megan; Elliott, Cecilie; and Kosiorek, Kathryn, "Ability of Flavonoids to Mimic the Estrogen Receptor to Drive Myeloid Derived Suppressor Cell Differentiation" (2019). Spring Showcase for Research and Creative Inquiry. 26.
https://digitalcommons.longwood.edu/rci_spring/26