BIOL 488: Effects of Cancer Mutations on the CREB-Binding Protein

CREB-Binding protein (CBP) works alongside the p300 protein as a coactivator complex to increase gene expression1. These proteins work together to bind to transcription factors and aid in expression through histone acetylation1. Together, they also are co-activators of the p53 tumor suppressor protein. In many cases, when there are mutations in CBP or p300, p53 is also mutated. The most important domains in the CBP are the bromodomain and the histone acetyltransferase domain. When functioning properly, CBP and p300 protein are tumor suppressors. When they have mutations, unregulated cell growth can occur.