High-performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS), and X-ray fluorescence (XRF) were used in order to obtain data to be used to develop the chemical profiles of several different brands and varieties of over-the-counter pharmaceutical tablets. Profiles of the organic components of the tablets were obtained via HPLC and GC-MS. Profiles consisting of the peak areas of common pharmaceutical ingredients were developed as well as profiles consisting of the full chromatograms for the tablets. Inorganic profiles were obtained via XRF. Profiles consisting of the peak areas of the elements identified within the tablets were developed as well as profiles consisting of the full spectra for the tablets. In order to group the different tablets together based on the developed profiles, chemometric analyses were utilized. Principal component analysis (PCA) and multivariate curve resolution-alternating least squares (MCR-ALS) were both used to group the tablets with related profiles. The above described methods and techniques can potentially be utilized by forensic scientists and applied to the chemical profiling and grouping of illicit substances manufactured by different individuals.
Crisp, Keith, "The Development and Analysis of Chemical Profiles of Various Over-the-counter Pharmaceuticals" (2017). Longwood Senior Theses. 19.