Document Type

Article

Publication Date

2017

Abstract

High-performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS), and X-ray fluorescence (XRF) were used in order to obtain data to be used to develop the chemical profiles of several different brands and varieties of over-the-counter pharmaceutical tablets. Profiles of the organic components of the tablets were obtained via HPLC and GC-MS. Profiles consisting of the peak areas of common pharmaceutical ingredients were developed as well as profiles consisting of the full chromatograms for the tablets. Inorganic profiles were obtained via XRF. Profiles consisting of the peak areas of the elements identified within the tablets were developed as well as profiles consisting of the full spectra for the tablets. In order to group the different tablets together based on the developed profiles, chemometric analyses were utilized. Principal component analysis (PCA) and multivariate curve resolution-alternating least squares (MCR-ALS) were both used to group the tablets with related profiles. The above described methods and techniques can potentially be utilized by forensic scientists and applied to the chemical profiling and grouping of illicit substances manufactured by different individuals.

Included in

Chemistry Commons

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.