Platinum-based drugs are commonly used as anti-cancer therapeutics due to their abilities to bind to DNA and prohibit proliferation in cells. Although the concept of drug interactions within biomolecules is often introduced in undergraduate courses such as biochemistry and toxicology, there are very few laboratory activities that exist that provide undergraduate students with the opportunity to investigate this topic in the lab. During the Summer 2020 PRISM program, we worked to create a multi-week laboratory activity for upper-level biochemistry students focused on the investigation of the DNA binding abilities of common Pt anticancer therapeutics through biochemical modeling and wet laboratory experience.
Naff, Keira, "Adaptation of Pt-DNA binding experiments into a multiweek upperlevel biochemistry laboratory activity" (2020). Fall Showcase for Research and Creative Inquiry. 26.