Document Type
Article
Publication Date
2011
Abstract
The synthesis and characterization of novel N-arylhydroxylamine-based molecular wires are described for use in the site-directed covalent immobilization of whole IgG antibodies onto gold electrode surfaces. The hydroxylamine, electrochemically generated in situ from reduction of the corresponding nitrobenzene, is stable under a wide range of solution conditions and reacts selectively with carbohydrate away from the antibody-binding site to allow the development of immunosensors with maximal activity. Cyclic voltammetric responses have shown a direct correlation between the structure and length of the molecular wire and its stability and concentration at the electrode surface.
DOI
10.1155/2011/609758
Version
Publisher's PDF
Recommended Citation
Williams, Dwight A.; Williams, Wraegen A. M.; Rhoten, Melissa C.; Crawley, Charlene D.; and Ruder, Suzanne, "Direct Immunosensor Design Based on the Electrochemical Reduction of 4-((4-Nitrophenyl) ethynyl) benzenethiol Monolayers" (2011). Chemistry & Physics Faculty Publications. 3.
https://digitalcommons.longwood.edu/chemphys_facpubs/3
Original Citation
Dwight A. Williams, Wraegen A. M. Williams, Melissa C. Rhoten, Charlene D. Crawley, and Suzanne Ruder, “Direct Immunosensor Design Based on the Electrochemical Reduction of 4-((4-Nitrophenyl)ethynyl)benzenethiol Monolayers,” Journal of Sensors, vol. 2011, Article ID 609758, 7 pages, 2011. doi:10.1155/2011/609758
