Authors

Antonio Harvey

Document Type

Article

Publication Date

12-6-2024

Abstract

This thesis explores the synthesis of a polyphenolic hemibastadin-1 derivative with presumed antimicrobial properties and improved biological safety. Structural modifications included replacing aromatic bromine atoms with phenolic groups and substituting the oxime linker group on the core structure for a triazole. A divergent synthetic strategy was designed with the dimeric nature of these targeted molecules in mind. Although this stepwise synthesis is not complete, the core triazole derivative was prepared with a respectable overall yield of 47% from the methyl gallate starting material. The final steps of the synthesis will require coupling of the divergent intermediates and deprotection of this benzylated dimer. Access to the polyphenolic hemibastadin-1 derivative will allow us to investigate its antimicrobial and biofilm-disrupting properties. We also intend to further derivatize this target compound and investigate how its structural modifications affect its antimicrobial properties.

Included in

Chemistry Commons

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