Document Type
Article
Publication Date
12-6-2024
Abstract
This thesis explores the synthesis of a polyphenolic hemibastadin-1 derivative with presumed antimicrobial properties and improved biological safety. Structural modifications included replacing aromatic bromine atoms with phenolic groups and substituting the oxime linker group on the core structure for a triazole. A divergent synthetic strategy was designed with the dimeric nature of these targeted molecules in mind. Although this stepwise synthesis is not complete, the core triazole derivative was prepared with a respectable overall yield of 47% from the methyl gallate starting material. The final steps of the synthesis will require coupling of the divergent intermediates and deprotection of this benzylated dimer. Access to the polyphenolic hemibastadin-1 derivative will allow us to investigate its antimicrobial and biofilm-disrupting properties. We also intend to further derivatize this target compound and investigate how its structural modifications affect its antimicrobial properties.
Recommended Citation
Harvey, Antonio, "The Investigation of the Antimicrobial and Biofilm-Disrupting Properties of Synthesized Hemibastadin Derivatives." (2024). Longwood Senior Theses. 39.
https://digitalcommons.longwood.edu/senior_theses/39